Amnio-Express® Test (Available only at Procrea Fertility Mont-Royal Office)

Waiting for the result of an amniocentesis can seem like an eternity when you want immediate reassurance. Thanks to the Amnio-Express® test, performed in conjunction with the amniocentesis, it is possible to obtain a result within 48-working hours for the most frequent chromosomal birth anomalies (trisomies 13,18,21, XXY and XO).

What is the Amnio-Express® test?

FISH technology* (technology using the Fluorescence In Situ Hybridization technique to analyze each chromosome) provides accuracy beyond 99.8% for the chrmosomes X, Y, 21, 18 and 13. Such a quick response is possible because a cell culture is not required for this type of analysis. To take advantage of Amnio-Express® test, it is important that you inform your physician who will be performing your amniocentesis that you want the Amnio-Express® test. Once notified, the physician will take an additional 5ml of amniotic fluid when drawing the fluid for the amniocentesis, without risk for your pregnancy. If you choose to have your amniocentesis done somewhere other than Procrea Fertility, you can still take advantage of the Amnio-Express® test by sending us a sample of your amniotic fluid.

Speak with your physician to learn if the Amnio-Express® test is right for you. The Amnio-Express® test is a service only offered at Procrea Fertility Montreal (Mont-Royal).

* FISH: The identification of the principal numerical chromosomal anomalies using the Fluorescence In Situ Hybridization technique.
Amnio-Express® is a registered trademark of GROUPE OPMEDIC INC.

Amniocentesis

Amniocentesis is a prenatal diagnostic procedure used to detect (or far more likely, to rule out) the presence of certain chromosomal anomalies in the fetus you are carrying. This test is performed during the second trimester of the pregnancy (between the 15th and 22nd week), generally during the 16th week.
Amniocentesis is performed in two stages:

• Abdominal puncture to extract some amniotic fluid.
• Laboratory culture of the fetal cells present in the sample of amniotic fluid followed by the analysis chromosomes.

The timeframe for analysis is 7 to 12 days. Several studies conducted worldwide have shown that ultrasound guided amniocentesis is safe for both the mother and her baby. There is however, a 0.5 to 1% risk of maternal infection and miscarriage (1).

Who is a candidate for amniocentesis?
• Any pregnant woman who, at her due date, will be 40 years of age or older.
• Any woman whose prenatal screen results are high risk (blood tests).
• Any woman whose ultrasound results indicate a potential fetal chromosomal anomaly.
• Any woman who has a family history or whose partner has a family history of one or more incidents of chromosomal anomalies or genetic disorders with a high recurrence risk.

Please note that a medical referral is always required. Speak with your physician to learn if an amniocentesis procedure is right for you.

(1) SOGC Guidelines, July 2015, number 326: Prenatal Diagnosis Procedures and Techniques to Obtain a Diagnostic Fetal Specimen or Tissue : Maternal and Fetal Risks and Benefits
Trisomy 21 by FISH

Trisomy 21

Normal chromosome 21